The principle of refined Hesperidin is mainly made by physical and chemical extraction process with the help of its special solubility properties. Hesperidin, also known as hesperidin and hesperidin-7-rhamnoglucoside, belongs to the group of dihydrocopper drugs. It has certain characteristics that it is insoluble in water, almost insoluble in benzene, acetone and chloroform, but it is slightly soluble in glacial acetic acid and methanol. Refined hesperidin in the production process will often be tangerine, orange, grapefruit, lemon, etc., soaked in water, crushed, washed, filtered dry, and then use its slightly soluble in glacial acetic acid and methanol, adding sodium hydroxide and methanol, dissolved in the filtration (dregs), adding hydrochloric acid acid acid crystallization, and finally drying of the cake to get the refined hesperidin.