A low-risk Down’s syndrome test means that the fetus has a low probability of having Down’s syndrome, and the pregnancy can usually continue without special treatment. Down’s syndrome screening is a blood test that screens for the risk of Down’s syndrome, or trisomy 21, and determines the risk of trisomy 18 and neural tube defects. However, Down’s syndrome screening is only a risk assessment, and the result is a risk value that can only be used for screening judgment, and there are false positives and false negatives. Therefore, a low risk Down’s syndrome test does not guarantee that the fetus is 100% free of Down’s syndrome, but only that the risk is relatively low. If the Down’s syndrome test is low risk, the mother should still have regular checkups during pregnancy, and mid-pregnancy checkups should be combined with systematic ultrasound screening to rule out any fetal abnormalities. If the Down’s syndrome screening result shows a critical risk, i.e., a gray zone, further non-invasive DNA testing is needed to clarify the diagnosis; if the risk is high, amniocentesis is needed to make a definitive diagnosis.