In patients with high jaundice, the total bilirubin is usually above 34.2 umol/L. At this time, patients need to determine the cause of the bilirubin elevation according to the type of bilirubin elevation, such as whether it is mainly direct bilirubin or indirect bilirubin elevation. In general, elevated bilirubin does not cause redness in the face of patients. If the face is red, it is also necessary to consider whether there are other possible causes, such as whether the patient has a combination of inflammatory infections, fever or autoimmune diseases such as lupus erythematosus. Therefore, for patients with redness of the face and combined with yellow sclera of the skin, in addition to blood sampling for liver function, further investigation of the patient’s immune system diseases is needed, and if necessary, liver aspiration biopsy is also needed to further determine the lesions of the patient’s liver. In addition, ultrasound and, if necessary, MRI or enhanced CT examinations should be done to further determine the possibility of other lesions in the patient’s liver.