Clinically, local anesthetics are often used to treat premature ejaculation, and commonly used drugs include lidocaine gel, benzocaine gel, etc.; the harm is that the use of anesthetics to treat premature ejaculation may produce certain side effects, and may also reduce the quality of sexual life. 1. Side effects: the drug may produce allergic reactions and hypersensitivity reactions; may also cause central nervous system excitation symptoms, including agitation, tinnitus, irritability, and so on, and may even develop into convulsions, coma blood pressure drop, etc.; when the blood concentration is too high, it may also cause ventricular fibrillation, cardiac arrest, atrial conduction slowdown, and so on. 2. Reduce the quality of sex life: the use of anesthetics can lead to penile numbness, which may affect penile erection; if you do not use a condom, it may also lead to vaginal numbness of the sexual partner, you will lose interest in sex and reduce the quality of sex life. It is recommended to standardize the use of drugs under the guidance of a doctor, and not to abuse drugs privately, so as not to cause harm to the body.