Moles in the palm of the hand can be removed by surgical excision, laser and other methods. Moles in the palm of the hand are a kind of benign hyperplasia originated from melanocytes, generally there is no change and no special treatment is needed. If they are often rubbed by external stimuli or have the risk of malignant changes, they can be removed by surgical excision, laser and other methods. 1. Surgical excision: generally through local infiltration anesthesia, surgical excision of pigmented nevus. 2. Laser: Smaller pigmented moles can be removed by the thermal effect of high temperature laser. If you have a mole on your palm and need to remove it, you should go to a regular medical institution for treatment and avoid abusing prescriptions or adopting unscientific methods on your own, so as not to cause other complications.