Evidence from evidence-based medicine is now being followed more in physicians’ practice, and the growing body of evidence from evidence-based medicine is directly influencing or shaping the development of medicine. Evidence-based medicine (EBM) is a philosophy, a process that combines the best evidence, physician experience, and patient wishes to make clinical decisions that are in the best interest of the patient. The best research evidence refers to real, clinically relevant studies that confirm accurate diagnostic tools, reliable predictors, and safe and effective preventive and therapeutic measures. Physician experience, or clinical expertise, means that physicians apply clinical skills and experience to quickly determine the effectiveness and risk of patient conditions, disease diagnoses, and optional therapeutic measures. Patient’s will refers to the patient’s expectations and preferences for medical treatment in the context of his or her condition and environment. In the 21st century, when prevention, prediction and individualized treatment are advocated, it is especially important for physicians to follow evidence-based medicine. Evidence from evidence-based clinical studies used in clinical decision making must be authentic. Authenticity refers to the correctness and reliability of the conclusions generated by a study, i.e., whether the results obtained reflect the true picture of the outcome to be measured. Internal veracity means that the clinical study correctly reflects the results that should be produced in the study population; external veracity means that the results with internal veracity are still valid when extended to similar populations outside the study population. Clinical research evidence can be divided into levels 1-5, with the highest level of evidence for high-quality randomized controlled trials and systematic reviews, which is level 5 evidence; the lowest level of evidence for expert opinion without analytical evaluation, which is level 1 evidence.