The use of antimicrobial drugs does not necessarily require skin testing. At present, the clinical need for skin testing of drugs is β-lactam antibacterial drugs, including penicillin, cephalosporins, other β-lactams, and so on. Clinical specific whether the need for skin test should be based on the patient’s specific circumstances, can not be generalized. 1. Penicillin: including penicillin, amoxicillin and other drugs. At present, China’s penicillin antibacterial drug manual requirements in the use of penicillin antibacterial drugs before the need to routinely do penicillin skin test. Penicillin skin test is the most rapid, sensitive and effective detection method for predicting penicillin fast-acting allergic reactions. 2. Cephalosporins: This class of drugs can be divided into four generations, which can include cefazolin, cefradine and other drugs. Most of the cephalosporin antibacterial drug instructions, the “Guidelines for the Clinical Application of Antimicrobial Drugs” and the “Pharmacopoeia of the People’s Republic of China Clinical Use of Drugs” do not require cephalosporins need to be routinely skin test before drug use. Clinical cephalosporins are not recommended to be routinely tested before use, but if there is a clear history of allergy to penicillin or cephalosporin type I (fast-acting), and if the drug specification requires skin testing, skin testing should be performed. 3. Other β-lactams: including amitranam, meropenem and other drugs. These drugs do not require routine skin testing prior to administration. If the instructions for these classes of drugs require a pre-administration skin test, refer to the cephalosporins. If skin test is required for taking antimicrobial drugs, you should go to the hospital immediately, undergo the relevant hospital examinations, and actively cooperate with the doctor’s treatment, and do not take care of it on your own.