Both high-grade and low-grade ductal carcinoma in situ belong to very early stage 0, only that the low-grade and high-grade are more early breast cancers, which are relatively milder and have a better prognosis. The specific differences between high-grade and low-grade ductal carcinoma in situ are the division of cancer cells, the risk of invasive carcinoma and the prognosis.
1. Division of cancer cells: High-grade ductal carcinoma in situ usually has obvious cytologic heterogeneity and high nuclear division activity. Low-grade ductal carcinoma in situ has only mild pleomorphism and heterogeneity, and usually has no necrosis.
2. Risk of invasive carcinoma: The risk of invasive carcinoma is higher in high-grade ductal carcinoma in situ. The risk of invasive carcinoma is higher in high grade ductal carcinoma, but invasive carcinoma does not occur in low grade ductal carcinoma in situ.
3. Prognosis: The prognosis of high grade ductal carcinoma in situ is worse. The prognosis of low-grade ductal carcinoma in situ is good after surgical excision.
It is recommended that all patients with ductal carcinoma in situ should go to the hospital in time for consultation and active treatment under the doctor’s guidance, so as to avoid delaying the condition.