High-grade ductal carcinoma in situ with microinvasion is usually not particularly serious. High-grade ductal carcinoma in situ with microinvasion mainly refers to the tumor type belongs to carcinoma in situ, and part of it has infiltrative changes, which indicates that the basement membrane is no longer intact at this time, and the cancer cells have already penetrated through the basement membrane and infiltrated outside the epithelial layer, with relatively high probability of invasion and metastasis, and the prognosis is a little bit poorer than that of carcinoma in situ without infiltration. However, on the whole, high-grade ductal carcinoma in situ with tiny infiltration is still in the early stage of cancer. For patients with good health and early detection, diagnosis and treatment, most of them can be cured through surgery to remove the lesions, and then cooperate with radiotherapy and chemotherapy afterwards.