The formation of non-suppurative thrombus in intracranial venous sinus is associated with mechanisms such as hypercoagulable state of blood, hereditary abnormality of coagulation mechanism, hemodynamic abnormality, systemic diseases, and pharmacological factors.
1. Hypercoagulable state of blood: it is mainly seen in abnormal coagulation function during pregnancy and puerperium.
2. Hereditary coagulation mechanism abnormalities: common protein S deficiency, VonWilebrand disease, coagulation factor Ⅱ, factor V gene mutation.
3. Hemodynamic abnormalities: including dehydration, shock, primary thrombocytopenia, primary erythrocytosis, disseminated intravascular coagulation, malignant stasis.
4. Systemic diseases: including leukemia, tumor, systemic lupus erythematosus, vasculitis, and antiphospholipid antibody syndrome.
5. Drug factors: including oral contraceptives, glucocorticoids, androgens and so on.
The specific pathogenesis of the disease is still unclear, the etiology is relatively complex, need to be combined with the patient’s own actual situation specific analysis.