Low HDL is an abnormality of lipid metabolism and can be treated with statins and niacin based on lifestyle improvement. HDL has the function of promoting the removal of cholesterol from peripheral tissues, so its reduced level may promote the development of atherosclerosis. For people with lowered HDL, the first step is to make lifestyle adjustments, including avoiding oily and high-salt diets, quitting smoking and drinking, and maintaining a certain intensity and frequency of aerobic exercise. If there is no improvement in HDL level on this basis, drug treatment needs to be considered. Under doctor’s guidance, statins such as atorvastatin, fibrates such as fenofibrate, niacin such as acyclovir, etc. can be used, and all of the above drugs have a certain effect on raising HDL. It is recommended that patients with low HDL should consult a doctor as soon as possible to avoid delaying their condition.