Old myocardial infarction cannot be cured, but the prognosis can be improved by applying drugs to reduce the burden on the heart and lower the chance of recurrent infarction. Myocardial cells in the ischemic area of old myocardial infarction are already necrotic, and myocardial cells cannot be regenerated, so patients’ cardiac function is often affected to a certain extent, and the clinical control of blood pressure and heart rate is often used to reduce the burden on the heart, and the commonly used medications include bisoprolol and valsartan, etc. Reducing the burden on the heart can effectively improve the prognosis of old myocardial infarction. Patients with old myocardial infarction should also pay attention to the prognosis of recurrent infarction. Clinical application of atorvastatin calcium tablets, resuvastatin, etc. is often used to control blood lipids and stabilize intravascular plaque, thus reducing the possibility of recurrent infarction. It is recommended that the patient should seek medical treatment to improve the cardiac function ultrasound and other tests to clarify the cardiac function and then be guided by a professional physician for treatment, in order to harvest the best prognosis.