The cause of nevus of Ota has not been fully clarified, usually there is no optimal treatment method, and the treatment methods mainly include laser treatment, other ways of treatment and so on. 1. Laser treatment: Nevus of Ota will cause serious impact on patients’ appearance, early detection and early treatment are recommended. Laser with specific wavelength and pulse width can be used to irradiate the local area and destroy the melanin particles inside the dermal melanocytes. The laser irradiation can make them rupture and the melanosomes are eliminated by phagocytes. 2. Other ways of treatment: Nevus of Ota with small area and shallow depth can also be treated in other ways. Commonly used clinical treatments, including chemical peeling, liquid nitrogen cryotherapy, etc., are mainly aimed at peeling off the skin at the pigmented spots. Nevus of Ota is generally not life-threatening, if there is a need for cosmetic treatment, you can go to the dermatology department of the hospital, combined with the doctor’s advice on treatment.