A one-and-a-half year old baby with high fever should first be treated with antipyretic therapy, and then the cause of the fever should be clarified and then targeted treatment should be carried out. Fever, first of all to measure the body temperature, if the body temperature is 38.5 ℃ or less, is in low fever, then the main physical cooling such as warm water wipe, at the same time to drink some warm boiled water. If the body temperature is greater than 38.5 ℃, need to follow the doctor’s advice to give antipyretic drugs such as acetaminophen, ibuprofen, etc. to control the body temperature, to avoid the occurrence of febrile convulsions. In the antipyretic treatment at the same time, but also need to complete the blood routine, blood culture, chest X-ray, electrocardiogram and other related tests, clear the cause of high fever in infants whether infectious fever. If the bacterial infection needs to be given sensitive antibiotics for anti-infection treatment, such as cefixime, etc.; viral infections are usually treated with supportive therapy. If the fever is not caused by infection, continue to improve the examination to clarify the cause and then carry out targeted treatment. High fever must be timely consultation, follow the doctor’s instructions for targeted treatment, so as not to miss the opportunity for treatment. All of the above drugs should be used under the guidance of a doctor.