In clinical work, a combination of 5 tests, ankle reflexes, pinprick nociception, vibration, pressure, and temperature sensation, are generally used to screen for diabetes-induced neuropathy. When type 2 diabetes is diagnosed, type 1 diabetes should be screened for diabetic neuropathy 5 years after diagnosis and then at least once a year. It is easy to detect and diagnose in those with typical symptoms. The most common early symptoms include pain and sensory abnormalities, but up to 50% of patients may be asymptomatic. Pinprick nociceptive and temperature sensory tests often reflect small-fiber nerves, while ankle reflexes, vibration sensation, and pressure sensation often reflect large-fiber nerves. Patients with diabetes should follow doctor’s instructions for standardized medication, strict blood sugar control and regular screening for diabetic complications to avoid serious consequences.