Cerebral thrombosis can not stop laughing is a disease, clinically known as strong smile. Cerebral thrombosis is often caused by blood clots blocking blood vessels, brain tissue hypoxia, ischemia, and then necrosis, softening and leading to corresponding symptoms. When patients with cerebral thrombosis have symptoms of not being able to stop laughing, it may be caused by damage to the neurological function of the brain, i.e., problems in the brain control area that controls the facial muscles, which requires increased vigilance and timely treatment. Treatment of cerebral thrombosis includes thrombolytic therapy, such as recombinant tissue-type fibrinogen activator; antiplatelet therapy, such as aspirin, clopidogrel, etc.; and fibrin-lowering therapy, such as defibrinolytic enzyme and bacitracin. Surgical treatment such as emergency endovascular surgery is needed when necessary. Cerebral thrombosis patients should usually correct the bad life and dietary habits, it is recommended to low-salt, low-fat, high-vitamin diet, and appropriate physical exercise, to enhance physical fitness, regular follow-up in the hospital. Drugs should be used under the guidance of a doctor.