Drugs used to treat urticaria include histamine H1 receptor antagonists (both first and second generation), histamine H2 receptor antagonists, glucocorticoids, and mast cell membrane stabilizers. Usually, patients with urticaria need to use first-generation histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine maleate or second-generation histamine H1-receptor antagonists such as loratadine and cetirizine under the guidance of a doctor. For acute urticaria, glucocorticoids such as prednisone and dexamethasone should be used on medical advice. Secondly, for patients with intractable urticaria, H2 receptor antagonists such as cimetidine and ranitidine should be used as prescribed by the doctor. In addition, mast cell stabilizers such as trinitrotoluene and ketotifen may be prescribed for some patients with severe symptoms. In addition, patients with urticaria need to remove the triggers in a timely manner, do a good job of personal protection, and strengthen the management of daily life, so as to avoid exacerbation of the condition. In short, urticaria patients must strictly follow the doctor’s instructions to use drugs, not unauthorized use of drugs, to prevent delayed treatment.