Chest pain caused by gastroesophageal reflux is characterized by the following features: it occurs behind the sternum, and the pain may radiate to the precordial area and other areas. Gastroesophageal reflux (GERD) is a disease in which uncomfortable symptoms and/or complications are caused by the reflux of gastroduodenal contents into the esophagus. The disease is mostly associated with the damage of the structure of the lower esophageal sphincter and the reduction of the barrier function of the esophageal mucosa. The main clinical manifestations are reflux and heartburn, and patients may also suffer from chest pain due to irritation of the esophagus by the reflux material. Chest pain occurs behind the sternum and may radiate to the precordial region, the back, the back of the ear, the neck, etc., and sometimes resembles angina pectoris. If it is not accompanied by reflux or heartburn, heart disease should be ruled out first to avoid delay. Gastroesophageal reflux, if not treated in time, may cause upper gastrointestinal bleeding, esophageal stenosis and other diseases, thus endangering the health of the body, it is recommended that the patient go to the hospital in a timely manner, and comply with the doctor’s instructions for standardized treatment.