Nasal hematuria is a common clinical symptom in patients with IgA nephropathy, which is related to glomerular injury caused by the disease.
IgA nephropathy is associated with congenital or acquired immunoregulatory abnormalities, and the disease is characterized by abnormalities in the immune system that result in an increase in IgA synthesis, which causes IgA-containing immune complexes to be deposited in the peritubular zone and activates the complement substitution pathway, resulting in glomerular injury. Localized defects in the glomerular capillary wall and rupture of the basement membrane result in leakage of red blood cells and the appearance of methemoglobinuria.
When the amount of bleeding reaches or exceeds 1ml/L, it can present the abnormal phenomena of urine such as granulocytic hematuria and erythrocyte tubular pattern, etc. Patients with IgA nephropathy who have simple granulocytic hematuria generally have a better prognosis, and it is enough to test the urinary protein and renal function on a regular basis; however, if proteinuria is combined with the disease at the same time, the patient should be actively treated for lowering the urinary protein.
Patients with IgA nephropathy are advised to consult the hospital in time to find out the cause, and should follow the doctor’s instructions to standardize the treatment.