The onset of the disease is slow and manifests as an intellectual impairment (dementia) syndrome. There are more women than men, about 2:1. 1. Early on, there is amnesia, and gradually memory impairment is manifested. Examination reveals short-term memory impairment, such as difficulty in retelling 3 items at 5-minute intervals and difficulty in learning new knowledge. The amnesia may increase later, and the forgetfulness may increase, and the person may lose things and forget as he/she goes along. Distal memory is also gradually impaired, and there is no recollection of major events that occurred in the past. Disorientation disorder is more obvious, such as being lost in the original familiar environment. In severe cases, even the names and ages of relatives are forgotten. Intellectual impairment, such as the ability to calculate, judge, analyze, synthesize, understand, reason, generalize, and create, and the inability to adapt to the social environment and engage in mental work, or in severe cases, even simple work, such as cooking. Often make mistakes, such as forgetting to turn off the gas or lock the door. The personality and self-knowledge are relatively intact in the early stage, but personality changes can be seen when the disease progresses, such as selfishness, stubbornness, unkemptness, collecting rags, and even lack of shame, public masturbation, and public urination and defecation, etc.; 4. 5. Temporal lobe dysfunction (e.g., visual loss, inability to recognize relatives or self in the mirror; repeatedly touching objects in front of the eyes), excessive eating, random eating, etc.); 6. Sleep rhythms are often disturbed, with excitement and sleeplessness at night, even noisy, and depression and drowsiness during the day; 7. In severe cases, incontinence and seizures may occur.