Septic meningitis is a bacterial infectious disease, and antibiotics should be preferred for treatment. The principles of antibiotic use for septic meningitis are early, adequate, regular, and adherence to medication. In the absence of a clear etiology, the use of third-generation cephalosporins, such as ceftriaxone or cefotaxime, which are common in clinical practice, should be adhered to. If the pathogen is clearly identified, it is important to select sensitive drugs for treatment in a timely manner. Generally speaking, antibiotics need to be used for at least 2-3 weeks and, in general, the cerebrospinal fluid needs to be brought down to normal levels before deciding whether to discontinue antibiotics depending on the situation.