Recently, Mr. Lin, who is in his seventies, went to the hospital for another checkup. The two years because of the occasional upper left abdominal pain, he is not sure how many times he has been bounced around a number of hospitals to find the cause. Continuous wasting, elevated blood amylase, left upper abdominal pain (pancreatic location) …… all signs point to pancreatitis and possibly even pancreatic cancer. However, CT, MRI and other imaging tests were normal again. Fortunately, this time the “unsolved” case of the old man’s abdominal pain was finally solved, and it turned out that he was suffering from macroamylasemia. This disease is relatively uncommon in clinical practice. The old man was 70 years old and was hospitalized in 2015 due to a history of gout for more than 10 years, taking hormonal drugs to control it on his own for a long time. During this period, because of the left upper abdominal pain, the doctor considered that the patient had been taking hormones for a long time and the patient had weight loss, so he was checked for blood and abdominal CT to rule out pancreatitis and pancreatic tumors. The results of the examination of Master Lin were somewhat surprising, as his blood amylase was high, but his lipase and urinary amylase were normal, and his kidney function and urinary ultrasound were normal. Uninterrupted left upper abdominal pain, elevated amylase, and wasting …… Once you think that Master Lin’s condition may be related to pancreatic cancer, it makes the old man’s family very nervous. The company’s main business is to provide a wide range of products and services to the market. After communication, the patient’s history of gout treatment raised the suspicion that “it could be mega-amylasemia”. Immediately, the doctors in the laboratory conducted a search and verification. The results did confirm the presence of macroamylase in the patient’s body. The truth is that Mr. Lin’s hyperamylasemia is probably related to the use of hormonal drugs for pain relief during his gout attacks and the immune disorder caused by long-term hormone use. The “gout spirit” that nine out of ten gout patients have eaten is actually a “fake drug” exposed by the State Food and Drug Administration, which contains anti-inflammatory painkillers, hormones, etc. Although it is effective in the short term, the cost is painful. Therefore, the doctor’s current treatment recommendation for Master Lin is to actively control the primary cause of gout to minimize or stop using hormones.