Atrial fibrillation chest tightness and shortness of breath, considering the heart rate is too fast caused by myocardial ischemia, you can take the drugs include drugs to control the ventricular rate, drugs to transfer atrial fibrillation, etc., and if there is a need for targeted treatment in the event of heart failure. 1. Drugs to control the ventricular rate: drugs such as metoprolol, digoxin and verapamil can effectively control the ventricular rate and significantly reduce the cardiac dysfunction caused by atrial fibrillation. 2. Drugs for reversing atrial fibrillation: drugs commonly used to reverse atrial fibrillation include quinidine, amiodarone and propafenone. 3. Patients with atrial fibrillation who have chest tightness and shortness of breath may also have heart failure, and can take drugs such as digoxin and bisoprolol to improve the prognosis of the disease. The above drugs should be used under the guidance of a doctor, due to individual differences, the drug is recommended under the guidance of a doctor combined with their own specific circumstances to choose the most suitable for their own medication, the emergence of adverse reactions should be timely consultation, drug allergy is prohibited.