Drugs to prevent premature ejaculation mainly include selective 5-HT reabsorption inhibitors, local anesthetics and so on. Specifically need to take medication under the guidance of a doctor, to avoid self medication. 1. Selective 5-HT reabsorption inhibitors, such as dapoxetine, can block the reuptake of 5-HT and elevate the concentration of 5-HT in the central nervous system, thus prolonging the patient’s ejaculatory latency. Side effects mainly include dizziness, nausea, and diarrhea. Contraindications include people with a serious cardiovascular past medical history, people with severe renal impairment, active peptic ulcers and bleeding disorders, people who have had recent strokes and heart attacks, and people who should avoid taking other medications while taking this product. 2. Local anesthetics such as lidocaine and other medications are applied topically to the glans. The aim is to reduce the sensitivity of the glans, thus prolonging the user’s ejaculatory latency. However, it should be noted that if too much is used it may result in the inability to have an erection. Contraindications include caution in patients with severe hepatic or renal dysfunction, decreased hepatic blood flow, congestive heart failure, severe myocardial damage, hypovolemia and shock. It should also be used with caution in those with pre-existing intraventricular conduction block. Specific anti-premature ejaculation drugs should be under the guidance of a doctor, the correct standardized use.