Quadruple drug therapy for TB refers to the combination of rifampicin, isoniazid, ethambutol, and pyrazinamide. The dosage varies from person to person. It is necessary to use the drugs correctly under the guidance of the doctor. 1. Rifampicin: The adult dose is 450-600mg orally once a day on an empty stomach. Adverse reactions include gastrointestinal discomfort and hepatic impairment. It is forbidden for those who are allergic to this product or rifamycin antimicrobial drugs, those with severe hepatic insufficiency, those with biliary tract obstruction, and pregnant women within 3 months. 2. Isoniazid: adult dose 300mg per day (or 4~8mg/kg per day), once orally; children 5~10mg/kg per day, once orally. Adverse reactions include peripheral neuritis and liver damage. It is contraindicated in patients with abnormal liver function, psychiatric patients and epileptic patients. 3.Ethambutol: the dose of adults and children over 13 years old are 15~25mg/kg per day, the beginning can be 25mg/kg per day, 2 months later reduced to 15mg/kg per day.Adverse reactions include retrobulbar optic neuritis, chills, arthralgias, skin rash, fever, etc.. It should be used with caution in pregnant and lactating women, and should not be used by children under 13 years old. 4. Pyrazinamide: Adult dose is 15~30mg/kg per day, once orally. Adverse reactions are hepatotoxic reactions, hyperuricemia, fever, malaise. It should be used with caution in pregnant and lactating women, diabetes mellitus, gout, severe hepatic decompensation, and is not suitable for children. Anti-tuberculosis drugs due to the more pronounced adverse reactions, the specific use of dosage should follow the doctor’s instructions, under the guidance of the doctor for anti-tuberculosis treatment.