The most painful weeks of radiotherapy are mainly related to the patient’s physical condition and tolerance. Generally speaking, the pain caused by radiotherapy is related to the radiation site and cumulative radiation dose. For example, the discomfort caused by radiotherapy to the internal organs is definitely greater than that caused by radiotherapy to the extremities and epidermis. In addition, the cumulative dose in the first week of radiotherapy is generally not large, and most patients do not have obvious discomfort symptoms, but with the accumulation of radiation dose, the discomfort reaction of radiotherapy will gradually increase. Moreover, due to the delayed response of radiotherapy, there will still be obvious discomfort for about 2 weeks to 1 month after stopping radiotherapy. In addition, the individual tolerance of radiation therapy may be different and the pain may be different. Patients can ease their pain through medication or dietary modifications under the specific guidance of their doctors. Although radiotherapy can cause different damage to the patient’s body, patients need to pay attention to the fact that they must adhere to radiotherapy in order to achieve the effect of adjuvant treatment. There are also some transfer methods to relieve the pain.