A, genetic factors: 1, that is, the relative prevalence increases with the group prevalence, the closer the relatives, the higher the prevalence, male prevalence is higher than female, usually male patients’ children only have cleft lip, but female patients’ children are more likely to occur at the same time cleft lip and cleft palate; the more serious the patient’s condition, the higher the prevalence of their relatives, with the number of affected children increases, the prevalence of cleft lip and palate of children born later As the number of children with cleft lip and palate increases, the prevalence of cleft lip and palate in children born later increases.
2, consanguineous marriage is 50%-100% higher than normal 3, racial characteristics of black people 0.4%, white people 1%, the Japanese higher 3%.
Second, the environmental factors: 1, nutritional factors animal experiments on the lack of vitamin B, A, E in the food of female mice, their pups often occur in the cleft lip and palate deformity.
2, endocrine influence on the 13-15 days of pregnancy in mice each injected with a dose of dexamethasone, 82% of its pups appear cleft palate.
3, the influence of drug factors taking tetracycline, salicylic acid, anti-epileptic drugs, anti-leprosy drugs, sleeping pills, reaction stop pregnant women, long-term exposure to pesticide women, easy to make the fetus occur cleft lip and palate.
4, biological factors within the first 3 months of pregnancy infected with viruses (such as rubella), can induce infants with cleft lip and palate.
5, injury and mental injury incomplete abortion can damage the embryo, directly affecting the development of the fetus mental stimulation can lead to increased secretion of adrenocorticotropic hormone in the body, in animal experiments, injection of adrenocorticotropic hormone can trigger cleft palate in young rats.
6, physical factors radiation, microwave infants can occur cleft lip and palate and other deformities.
7, the impact of tobacco and alcohol smoking, alcohol consumption of pregnant women, the incidence of cleft lip and palate in infants is higher.