(1) Diuretic and decongestant (1) Dihydrocotrimoxazole 25mg each time, 3 times a day. (2) Tachyphylaxis: 20mg every time, 3 times a day, or intravenously if edema is severe. (3) Amphotericin 20mg 3 times a day. (4) Aminopterin 50mg each time, 3 times a day. 2, actively control hypertension In chronic nephritis, the remaining and/or diseased renal units are in a compensatory high hemodynamic condition, systemic hypertension undoubtedly aggravates this lesion and leads to progressive glomerular damage, so patients with chronic nephritis should actively control hypertension to prevent deterioration of renal function. 3, coagulation and platelet depolymerization drugs In recent years, most studies have shown that anticoagulation platelet depolymerization drugs on certain types of nephritis (such as IgA nephritis) in long-term clinical follow-up and animal experimental nephritis model studies, showing good stabilization of renal function, reducing the role of renal pathological damage. There is no uniform protocol for the application of anticoagulation and platelet depolymerization therapy in chronic nephritis, but it is generally believed that certain types of pathologies that are prone to hypercoagulability (e.g., membranous nephropathy, thylakoid capillary proliferation nephritis) can be applied for a longer period of time. The main drugs are: (1) Pansentin 25-50 mg 3 times a day. (2) Enteric aspirin 40~80mg per time, 3 times a day. 4. Hormones and cytotoxic drugs There is no uniform view at home and abroad on whether to apply hormones and/or cytotoxic drugs in chronic nephritis, and it is generally not advocated to apply them. If the patient’s renal function is normal or only mildly impaired, the kidney volume is normal, urine protein ≥ 2.0g/24h, the pathological type is mild thylakoid proliferative nephritis, mild lesions and other mild lesions, such as no contraindications can be tried hormones and cytotoxic drugs, and gradually withdrawn if ineffective. (1) Glucocorticoids: Patients with microscopic lesions and mild tegumentary proliferative nephritis are less responsive to glucocorticoid therapy than pediatric patients, and the general course of treatment is 6-20 weeks, with an efficiency rate of about 80%. Currently, prednisone or prednisolone is mostly used. The latter is several times more expensive than the former, and in those with normal liver function, the former becomes the latter and works, so the former is usually sufficient. The dosage is very inconsistent, some are divided into doses, some are taken at once, and some are taken every other day. The common method in China is to start with a dose of 40~60mg/d, divided into 3~4 doses or one dose in the early morning, and maintain for 8~12 weeks. If the dose is effective (diuresis appears about 1 week after dosing, and urine protein is obviously reduced or even disappears about 2 weeks after dosing), the dose is gradually reduced by about 5%~10% of the original dose every 2~3 weeks. When the daily dose is reduced to 10~15mg, the dose can be changed to alternate day doses (i.e., the total amount of 2 days can be taken every other morning), and the dose can be reduced to the minimum effective amount and maintained for 6~12 months. The key to the success of this drug treatment is to start with sufficient dosage, sufficient time to induce the use of high doses, and slow reduction of effective people. (2) Cytotoxic immunosuppressants: These drugs alone are less effective than glucocorticoids in the treatment of chronic nephritis. But for the “hormone-dependent” and “hormone-resistant” people combined with glucocorticoids, there are auxiliary effects, commonly used drugs: cyclophosphamide, the daily amount of 100 ~ 150mg, divided into 2 ~ 3 oral. Or 200mg, orally once a day or every other day. The total amount is 6~8 g. Exceeding this total amount does not improve the efficacy, but significantly increases the side effects. Cyclosporine A, the initial dose is 3~5mg/kg.d, then adjust the dose to reach the drug’s blood valley concentration of 100~200ng/L. The general course of treatment is 3~6 months, long-term use has hepatic and renal toxicity.