Fever over 39℃ is considered high fever, and whether it is serious depends on the patient’s condition. If the face is normal, there is no headache, vomiting, abdominal pain, diarrhea and other symptoms, it is generally not serious. If the fever continues to be high and confused, along with other adverse reactions, the condition is more serious. Fever is an important clinical manifestation in the course of disease progression. A fever over 39℃ that lasts all night without other uncomfortable symptoms is generally not a serious problem, but more attention should be paid to observe the patient’s status because prolonged high fever can lead to mental and delirious changes and also easily cause symptoms such as dehydration of the body, generalized aches and pains, and headache, which may lead to damage to the functions of various organs, and in severe cases, febrile convulsions and even life-threatening. Therefore, early treatment of fever reduction, drinking more water as well as giving physical cooling, such as ice packs, warm water baths, etc., and also oral non-steroidal anti-inflammatory drugs, such as ibuprofen granules, acetaminophen, etc., are recommended. Therefore, in this case, the first thing is to actively give antipyretic treatment, if necessary, promptly go to the hospital, improve the relevant examination, clear the cause of fever, and then the corresponding treatment, so as not to delay the disease.