The causes of cirrhosis include the following eight aspects: (1) Hepatitis virus: The most common are hepatitis B virus, hepatitis C virus and hepatitis D virus infections. Chronic hepatitis occurs in some people infected with hepatitis B virus, and a small percentage of chronic hepatitis B develops into cirrhosis. About half of acute hepatitis C develops into chronic hepatitis, and 10-30% of them develop cirrhosis. Hepatitis D virus depends on hepatitis B virus before hepatitis can occur, and some patients develop cirrhosis. (2) Alcohol factor: long-term heavy drinking leads to liver cell damage, fatty degeneration, necrosis, liver fibrosis, and in severe cases, cirrhosis. (3) Biliary stasis: Long-term chronic biliary stasis leads to inflammation of hepatocytes and bile duct reaction, and even necrosis, forming biliary liver sclerosis. (4) Stasis factors: Long-term recurrent chronic cardiac insufficiency, constrictive pericarditis and hepatic vein obstruction can cause liver stasis, causing necrosis and degeneration of hepatocytes due to lack of oxygen, which eventually leads to cirrhosis. Among them, cirrhosis caused by the heart is called cardiogenic cirrhosis. (5) Drug or chemical toxic factors: Long-term use of certain drugs, such as diphenhydramine, cinchon, methyldopa, etc., can lead to drug-related hepatitis, and eventually develop into cirrhosis. Long-term exposure to certain chemical toxins, such as carbon tetrachloride, arsenic, phosphorus, etc. can cause toxic hepatitis, which develops into cirrhosis. (6) Metabolic disorders: copper metabolism disorders, seen in hepatomegaly. Iron metabolism disorders, seen in hemophilia, galactosemia, fibrous cysticercosis, alpha-antitrypsin deficiency, glycogen storage disease, tyrosine metabolism disorders, hereditary hemorrhagic capillary dilation, the above conditions are related to genetic metabolic defects, can lead to cirrhosis. (7) Parasitic infection: Schistosoma haematobium infection is common in the south of China and can lead to schistosomiasis, which further causes liver fibrosis leading to cirrhosis. Human infection with Toxoplasma gondii can lead to cirrhosis after untimely treatment. (8) Other factors: High malnutrition can lead to cirrhosis, and a small number of cirrhosis of the liver for unknown reasons.