Interstitial cystitis is one of the relatively rare diseases in urology, with an incidence of about 10.6 out of 100,000 people, relatively common in women, the onset is generally subacute and rapidly develops into interstitial cystitis is one of the relatively rare diseases in urology, with an incidence of about 10.6 out of 100,000 people, relatively common in women, the onset is generally subacute and rapidly develops into acute. The pathological changes are: increased permeability of the bladder wall, interstitial tissue fibrosis, edema, mononuclear cell infiltration, bladder wall hemorrhage and mononuclear cell infiltration in the detrusor muscle after bladder water dilatation. The main manifestations are pain in the bladder area or lower abdomen with urinary tract irritation and a negative urine culture. The necessary conditions for its diagnosis include two categories: 1, point-like hemorrhage or Hunner ulcer in the mucosa of the bladder, the bleeding site should be perfused with 89 cmH2O for 1-2 minutes under anesthesia and at least 3 foci of hemorrhage in the bladder mucosa can be observed.
2. Pain in the bladder area with urinary urgency.
Treatment: 1. Antidepressants Amitriptyline is a tricyclic antidepressant that can be used to treat interstitial cystitis. Effects include: anticholinergic effects on central and peripheral nerves; blocking histamine receptors and stimulating adrenergic receptors, which reduces smooth muscle excitability and promotes urinary storage in the bladder. Treatment for at least three weeks, the dose increased from 25mg to 75mg. 2, intravesical instillation Silver nitrate Its contraindication is ureteral reflux, the cure rate of this means is 14%, the efficiency is 70%.
Dimethyl sulfoxide 50% solution bladder instillation, kept for 15 minutes, not repeated once in 2-4 weeks. Acute. The pathological changes are: increased permeability of the bladder wall, interstitial tissue fibrosis, edema, mononuclear cell infiltration, bladder wall hemorrhage and mononuclear cell infiltration in the forced urinary muscles after bladder water dilatation. The main manifestations are pain in the bladder area or lower abdomen with urinary tract irritation and a negative urine culture. The necessary conditions for its diagnosis include two categories: 1, point-like hemorrhage or Hunner ulcer in the mucosa of the bladder, the bleeding site should be perfused with 89 cmH2O for 1-2 minutes under anesthesia and at least 3 foci of hemorrhage in the bladder mucosa can be observed.
2. Pain in the bladder area with urinary urgency.