In stage 3 diabetic nephropathy, 2-hour postprandial blood glucose 10.3mmol/L is generally not considered serious, but whether it is serious or not needs to be assessed whether the weekday blood glucose control is good or not. If weekday blood sugar control is good, with occasional elevation of blood sugar, active treatment can slow down the progression of kidney disease, which is relatively not serious; if weekday blood sugar control is not good, it may accelerate the progression of the disease, and eventually develop into uremia, which is more serious. Diabetic nephropathy stage III is kidney damage caused by diabetes. Under normal circumstances, the standard value of 2-hour postprandial blood glucose is ≤7.8mmol/L. If the patient has good glycemic control on weekdays and occasional elevation of blood glucose, the progression of renal disease may be slowed down by actively controlling blood glucose and preventing complications and other treatments, which is relatively not serious at this time. If patients have poor glycemic control on weekdays, when the 2-hour postprandial blood glucose value is 10.3mmol/L, a series of adverse reactions such as thirst, polyuria, fatigue, easy to hunger, and even coma, etc., and at the same time, it may accelerate the progression of the disease and soon develop into uremia, which is more serious at this time. Patients with diabetic nephropathy are advised to go to regular hospitals in time and standardize the treatment under the guidance of doctors.