Diabetic foot with ulceration should firstly identify the cause of the disease and then treat the cause. If the ulceration is caused by fungal infection, antifungal drugs can be used. The treatment of diabetic foot generally includes controlling blood sugar, treating the cause, symptomatic treatment, surgical treatment, etc. There is no such thing as the nemesis of diabetic foot ulcers, please follow the doctor’s instructions for treatment. 1. Glucose control: through oral acarbose, metformin and other hypoglycemic drugs or insulin injection therapy, with diet control and appropriate exercise to control blood glucose within a reasonable range can prevent and delay the occurrence and development of diabetic foot. 2. Treatment of cause: diabetic foot caused by neuropathy can be treated with α-lipoic acid, which can improve nerve sensory abnormality and conduction abnormality; diabetic foot caused by vascular pathology with reduced blood flow in the lower limbs can be treated with anti-platelet aggregation drugs such as aspirin and clopidogrel. 3. Symptomatic treatment: antibiotics such as cefuroxime can be used for patients with combined infection. 4. Surgical treatment: For diabetic foot with ulceration, we can consider debridement and skin grafting to remove necrotic tissues; we can also consider vascular bypass surgery and endoluminal intervention of lower limb arteries. Patients diagnosed with diabetic foot should actively cooperate with doctors for treatment, and maintain a good lifestyle and healthy eating habits are conducive to the recovery of the disease.