The disease is a recurrent blistering skin disease that occurs on the skin of the palmoplantar and flexor side of the fingers and toes, often accompanied by excessive sweating of the hands and feet. The etiology and pathogenesis of the disease are not fully understood, but it may be an eczema-like metaplasia that occurs in the skin. There is no obvious damage to the small sweat glands themselves and no sweat retention, but reducing sweating in the palmoplantar area helps clinical remission. Psychological factors, focal infections (especially lichen planus), local allergy or irritation, allergic constitution and neurological dysfunction may be associated with the development of the disease. Individuals have a family history. Clinical manifestations】 The disease occurs on the palms of the hands, soles of the feet and the sides of the fingers (toes). The lesions are small, round, corn- to soybean-sized blisters located deep in the epidermis, without a surrounding redness, containing clear plasma or becoming cloudy, and the blisters can fuse into large blisters, but generally do not rupture on their own and form collar-like flakes after drying. The blisters may fuse into large blisters, but usually do not rupture on their own and dry up to form collar-like flakes. The course of the disease is chronic, but is prone to recurrence in spring and autumn. Diagnosis and Differential Diagnosis】 Based on the location, typical lesions and tendency to recur, the disease is not difficult to diagnose. The disease needs to be differentiated from tinea cruris, exfoliative keratolytic disease, etc. Treatment】 Avoid mental tension and mood swings, find and remove contact irritants, and treat excessive sweating of the hands and feet appropriately. Early in the course of the disease, antihistamines can be applied, and local medication is based on the principles of dryness, anti-inflammation, and antipruritus, such as topical application of dermatophyte, etc. In the later stages of the disease, when flaking is the main cause, topical application of 10% urea cream can be used.