The fourth-generation HIV test is actually a test for HIV antigens and antibodies. The fourth-generation test is relatively accurate, as it detects antibodies and antigens in the infected person’s body about 2-3 weeks after infection, allowing for a definitive diagnosis. Even if the fourth generation test is positive, a confirmatory test is required by the CDC to confirm the diagnosis of AIDS. The confirmatory test is a retest of HIV using a protein blot test. If the protein blot test is also positive, the patient will be diagnosed with HIV. Once the infection is confirmed, the patient should be treated with antiviral drugs as soon as possible.