DD used genetic engineering techniques to improve the former plague-causing Salmonella into a new generation of vaccines for pneumonia. This vaccine carries the gene of the pneumococcus into the human body and causes a strong immune response against the pneumococcus, producing high titers of antibodies and protecting people from pneumonia. The invention received widespread attention from the medical community as soon as it was introduced, with a full report in a leading foreign media outlet (Redorbit). It provides a novel approach to novel vaccine research and has great promise in the treatment of infectious diseases and malignancies.
Salmonella is originally a bacterium that causes typhoid fever. Typhoid fever is an acute infectious disease, and in ancient times, when there was a shortage of medicine, typhoid fever had a large outbreak with a high death rate, and people talked about typhoid fever. Typhoid is rampant because the culprit DD Salmonella unique invasion channels that cause typhoid. Unlike general bacteria that invade the body and multiply only locally, thus causing weak virulence, Salmonella invades the body and quickly enters the systemic lymph nodes and important lymphatic organs such as the spleen and bone marrow, causing systemic spread of virulence and systemic lymphatic reaction. Patients will have fever, diarrhea, swollen lymph nodes and other symptoms, and even die from toxic encephalopathy, toxic hepatitis, and toxic myocarditis.
While people are respectful of Salmonella, Professor Li Yuhua of Zhujiang Hospital has turned the corruption into magic by using the characteristics of Salmonella to spread through the systemic lymphatic tissues, allowing it to carry pneumococcal genes to easily enter the body’s immune system, causing a strong systemic immune response against pneumococcus, effectively solving the problem of low immune response caused by existing vaccines. However, people cannot help but question: Salmonella is very virulent, and after entering the human body as a live vaccine, will it continue to multiply and cause harm to the human body?
“We have used genetic engineering methods to modify Salmonella, and the modified Salmonella is very safe and will not cause damage to the human body.” Professor Li Yuhua’s affirmative answer dispelled our doubts, “Salmonella needs mannose and arabinose to grow, these two sugars do not exist in the human body, ordinary Salmonella can use their own enzymes to convert other sugars into these two sugars, but the Salmonella vaccine modified by us, due to genetic mutations, can not use other sugar synthesis. Their growth was not affected in the in vitro medium containing mannose and arabinose, but once they entered the in vivo environment lacking mannose and arabinose, they could not continue to synthesize mannose and arabinose. When the original mannose and arabinose are depleted, the bacteria are completely attenuated and die quickly. In this way Salmonella dies automatically after completing its mission without causing harm to humans.”
Professor Li, who has been working on the Salmonella vaccine for more than 10 years, said the trial results of the new Salmonella to prevent infection by S. pneumoniae were successful, and the modified Salmonella vaccine produced higher antibody titers and better protection than the traditional Salmonella vaccine. In 2009, the new Salmonella vaccine was approved for clinical trials for the prevention of pneumococcal infections. In the near future, people will use this smart salmonella vaccine to effectively prevent pneumonia and even combat malignant tumors.