Paroxysmal sleep hemoglobinuria medication is mainly to control hemolysis, commonly used drugs include dextrose, sodium bicarbonate, eculizumab, stanozolol and glucocorticoids. 1. Patients with paroxysmal sleep hemoglobinuria may suffer from increased blood cell destruction, which may lead to symptoms such as hemoglobinuria and anemia. Dextrose anhydride and sodium bicarbonate can control acute hemolysis, and eculizumab can block the complement activation pathway and relieve hemolytic symptoms. 2. Androgen stanozolol, can stimulate erythropoiesis, if iron deficiency anemia occurs, can take a small dose of ferrous sulfate. 3. Glucocorticoids can reduce the concentration of complement in the blood and alleviate hemolysis, commonly used are dexamethasone, prednisone and so on. 4. Paroxysmal sleep hemoglobinuria patients may lead to moderate-to-severe anemia, at this time the need for transfusion of red blood cells, can supplement hemoglobin, improve tissue oxygen supply, but also inhibit erythropoiesis, indirectly reducing the complement-sensitive erythrocytes, reduce hemolysis. 5. Some patients may have blood clots and need anticoagulation therapy, such as warfarin. Paroxysmal sleep hemoglobinuria medication needs to strictly follow the doctor’s prescription, the doctor will give the appropriate medication according to the patient’s specific situation.