Paroxysmal sleep hemoglobinuria (PNH), which belongs to the category of “hemoglobinuria (the appearance of blood in the urine accompanied by pain)” in traditional Chinese medicine, is generally difficult to be cured by traditional Chinese medicine, but the use of traditional Chinese medicine to identify and treat the symptoms can be improved, which can be divided into the symptoms of qi and blood deficiency, deficiency of the spleen and kidney, and dampness-heat internalization. 1. Double deficiency of qi and blood: dizziness, palpitations, fatigue (lack of spirit), laziness, occasional soy sauce-colored urine, pale or yellowish face, shortness of breath, mild yellowish sclera, pale lips. The treatment is to benefit qi and nourish blood, and the formula is tonifying zhong yi qi tang or gui spen tang with additional subtractions. 2. Spleen and kidney deficiency: waist pain and leg weakness, loose stools, frequent urination at night, poor appetite, colorless face, weakness of limbs, fear of cold, and fat tongue. The treatment is to tonify the kidney and strengthen the spleen, and the formula is 14-flavored Jianzhong Tang plus subtractions. 3. Damp-heat internalized evidence: dry stool, tiredness, fatigue, poor appetite and nausea, yellow sclera and skin, tea-colored or soy sauce-colored urine, white face, or fever. Treatment is to clear away heat and eliminate dampness, supplemented by benefiting Qi and nourishing Blood. The formula is Yin Chen Wu Ling San plus subtractions. Chinese medicines or proprietary Chinese medicines need to be used under the guidance of a Chinese doctor to identify the symptoms, and individuals should not use them blindly to avoid adverse consequences.