The pituitary gland is an important secretory organ located at the base of the human brain. Although it is the size of a green pea, it secretes a variety of hormones that play a vital role in human growth, development, metabolism and reproduction. Perhaps the chronic overload of the pituitary gland makes it one of the good sites for tumors. Pituitary tumors are reported to be the third most common intracranial tumor, and about 1 in 5 adults may have a pituitary tumor. Tumors of the pituitary gland can present with different clinical symptoms due to excessive or low secretion of pituitary hormones. Pituitary tumors causing gigantism due to excessive secretion of growth hormone are rare, less than 1% of pituitary tumors, and can occur in both sexes, only in children and adolescents. Therefore, parents should pay attention to whether their children have precocious puberty, hyperphagia, and rapid abnormal height increase, which will help early detection. If it occurs in adulthood, the child’s height will not grow, but the hands and feet will become abnormally large, which is the common clinical condition called acromegaly. Even if gigantism is indeed caused by pituitary tumors, there is no need to panic. A visit to the neurosurgery and endocrinology departments of a hospital can help confirm the diagnosis through blood pituitary hormone testing and MRI of the head, as well as help rule out the possibility of non-pituitary causes of hypertrophy. Depending on the size of the tumor, growth hormone and other endocrinology tests, the neurosurgeon may treat the condition with medication, microsurgery or stereotactic radiosurgery. For adult patients with pituitary tumors in gigantism, it is recommended to pay attention to blood pressure, blood glucose and heart function tests, as well as to the control of blood pressure and blood glucose and the occurrence of premature aging. With the progress of modern medicine and the deepening of genomic and post-genomic research, the treatment and prevention of pituitary adenoma will take a new step forward as the mystery of pituitary adenoma pathogenesis is being gradually uncovered.