Acromegaly is caused by a kind of pituitary tumor known as growth hormone tumor, mainly this pituitary tumor will secrete a large amount of growth hormone, thus causing a series of clinical manifestations, due to the slow onset, early symptoms are not typical, many patients were found when the tumor has been larger, the complications are also more serious, early discovery, proper management is to increase the cure rate of acromegaly and improve the quality of life is very important. Early detection and proper management are very important to improve the cure rate and quality of life of acromegaly. Typical clinical manifestations of acromegaly: Typical appearance of hypertrophy of limb ends, including large limbs, large feet, large nose, thick lips, high zygomatic arches, long head shape, prominent eyebrow arches, protruding mandible, long jaw with sparse teeth and reverse occlusion, hypertrophy of tongue, thick skin and so on, long time no see friends when seeing you again, they will say that people have changed their appearance, and become uglier; other manifestations include the manifestations of each affected system, central nervous system, headache, visual field defects; cardiovascular, cardiac, and other symptoms. Headache, visual field defects; cardiovascular hypertension, ventricular thickening, heart failure in severe cases; respiratory obstructive respiratory sleep disorder, respiratory failure in severe cases; visceral organs enlargement; metabolic system will appear elevated blood glucose; bone and joints involved in cartilage hyperplasia, osteoarthropathy, etc.; the reproductive system is affected by amenorrhea, lactation, infertility of females, and sexual dysfunction of males; it will also appear oncological disorders such as colon cancer, etc. These all seriously affect the health and survival of patients. All these seriously affect the health and survival quality of patients and shorten their life span. Therefore, when the typical symptoms mentioned above appear, it is necessary to go to the endocrinology department in time. However, the problem is that typical symptoms often appear years after the disease has progressed, when complications are serious and treatment is more difficult. Therefore, early screening is very important, who needs special attention? When a patient does not have the characteristic symptoms of limb enlargement, but has 2 or more of the following symptoms, the possibility of limb enlargement should be considered and screening should be performed: new-onset diabetes mellitus; multiple episodes of joint pain; new-onset or difficult-to-control high blood pressure; cardiac disease such as ventricular hypertrophy or systolic or diastolic dysfunction; malaise, headache, carpal tunnel syndrome, sleep apnea syndrome, hyperhidrosis, loss of vision, colonic polyps, and progressive jaw protrusion. protruding jaw.