Blood blisters are usually self-absorbing in about 1-2 weeks without provocation, with individual differences in time. Blood blisters are mainly caused by local irritation, trauma or disease factors. Patients should first exclude blood-related diseases, such as thrombocytopenia, diabetes or coagulation factor deficiency. After exclusion of disease factors, patients are advised to seek prompt medical standardization, i.e., disinfection and extraction of fluid and blood from the blister, and disinfection and pain relief with relevant medications under the guidance of a medical professional. Without puncture and fluid extraction, the self-absorption time will be relatively long, about 1-2 weeks, with some patients taking even longer to recover. Patients need to pay attention to keep the affected area dry after the puncture and disinfect it with iodophor daily to avoid local secondary infection. If blood blisters appear, it is recommended to go to the hospital dermatology department for clear diagnosis and standardized treatment in a timely manner to avoid delay.