The sole of the foot rotted a lot of small holes, may be the fossa keratolysis, is caused by the rod-shaped bacillus genus of metatarsal cuticle exfoliation of a dermatosis, often occurs in the metatarsal region, the patient tends to sweating, malodor, lesions are superficial punctate cuticle pits, can be fused into irregular depression or erosion. There is a possibility of accompanying fungal infection and itching with the development of symptoms. If the symptoms are mild, keep the local clean and dry can be, if the symptoms are more obvious, usually medication, for such symptoms can be considered to take the following methods of treatment: 1, topical medication: usually topical erythromycin ointment, fusidic acid cream, tetracycline ointment and so on, to prevent bacterial growth, improve the local malodor reaction. If the local inflammatory exudation and moist symptoms are obvious, zinc oxide ointment can be applied to reduce the inflammatory fluid exudation; 2, oral drug treatment: usually oral vitamin B1 and other oral treatment, such as fungal infections, oral antiseptic drugs, such as itraconazole or terbinafine and so on. In addition, if accompanied by symptoms of itching, but also under the guidance of the doctor oral antihistamine drugs to stop itching, such as levocetirizine hydrochloride, loratadine, etc.; if accompanied by foot exfoliation of the stratum corneum, may be accompanied by exfoliative keratolysis, can be externally applied to the ointment of urea, polysulfonic acid mucopolysaccharide ointment and so on. It is also important to pay attention to local cleanliness, protect the skin, do not use irritating cleaning products, change shoes and socks diligently, pay attention to foot hygiene, keep dry and reduce sweating. If the symptoms have not improved, actively go to the regular hospital dermatology department for further treatment.