The numbness of the soles of the feet is mainly seen in peripheral neuropathy, subacute joint degeneration, lumbar spine lesions, as follows: first, peripheral neuropathy: seen in peripheral neuropathy, such as patients with diabetes, and the emergence of bilateral or one side of the soles of the feet numbness, to consider the possibility of diabetes caused by peripheral neuropathy, you can carry out the examination of electromyography. The treatment is mainly to control the blood sugar, and at the same time give the treatment of nutritional nerve. Second, subacute combined degeneration: ask the patient whether there is any history of chronic gastritis or gastric surgery, and whether there is any weakness of both lower limbs, accompanied by unsteady walking, walking on cotton-like sensation, need to consider the subacute combined degeneration, and can be given to the blood test for vitamin B12, homocysteine, lumbar spinal puncture, electromyography, and cranial and cervical spine MRI examination. Treatment is given to nutritional nerve, such as vitamin B12, folic acid and other treatments. Third, lumbar spine lesions: If the numbness of the sole of the foot is unilateral, we should also consider whether the patient has lumbar spine lesions, we can carry out lumbar spine magnetic resonance examination to know whether there is any lesion in the lumbosacral region, and we should give nutritive nerve drugs, such as vitamin B1, vitamin B12 and other symptomatic treatment.