Sciatica painkillers potent drugs include the following: 1. Commonly, they are non-steroidal anti-inflammatory and analgesic drugs. It is a selective inhibitor of COX2, which selectively inhibits arachidonic acid to avoid further damage to the stomach, and is the most commonly used, safest, least side effects, and most effective painkiller. 2. The side effects of these drugs are relatively more than those of Acomplia, but the clinical application is relatively cheap, and the application range is relatively wide, and the effect is generally good.