Premature ejaculation is a common sexual dysfunctional disorder in men, which belongs to ejaculation disorder and has a relatively high incidence in men. The definition of premature ejaculation is still controversial in academic circles, but the one that has gained more recognition is the subjective definition given by the American Psychiatric Association/American Urological Association guidelines: ejaculation before or within a short period of time after penetration, ejaculation is not desired by the patient, causes frustration for the patient or the patient and the sexual partner, and the situation is persistent or recurrent and is not the direct effect of a substance. In other words, normal men can control their ejaculatory behavior and can decide when they will ejaculate by virtue of their subjective will, whereas an important characteristic of premature ejaculation patients is that they cannot control the ejaculatory impulse by their own will power alone. For the cause of premature ejaculation, the traditional view is that premature ejaculation is largely attributed to psychological causes. As research progresses, it is gradually realized that this is a multifactorial disease that is associated with psychological, environmental, endocrine, and neurobiological factors. Many patients with premature ejaculation associate their condition with earlier experiences of masturbation. There is no solid evidence to support this view in terms of pathophysiological mechanisms, although emotional factors triggered by masturbation are likely to be a causal factor in premature ejaculation. Usually, masturbation is done in a dysfunctional environment, and the person tends to want to ejaculate as quickly as possible, which in the long run creates such an excitement in the brain. Even if you have a normal sex life later, it will take time for the excitement to go away, so the risk of developing premature ejaculation is also higher than normal people. For premature ejaculation, medication is currently the most mainstream treatment. Previously, antidepressants were mostly used off-label. Despite their efficacy, there are safety concerns because antidepressants are not indicated for premature ejaculation. Dapoxetine, approved for marketing in China in 2013, is the only medication prescribed today for the indication of premature ejaculation. It is a ready-to-use medication for premature ejaculation that works 1-3 hours before sex. From the current clinical observations, dapoxetine is not only efficacious but also safe enough to be used.