Patients with acute pelvic inflammatory disease should undergo targeted treatment according to the severity of their condition at the onset. Patients with acute pelvic inflammatory disease should rest in bed, replenish fluids, correct electrolyte disturbances and acid-base balance if their condition is mild, and physically cool their body when they have a high fever. The patient can also visit the hospital and choose antibiotics according to the drug sensitivity test, the more severe cases should be selected with broad-spectrum antibiotics, the combination of drugs is effective, the route of administration to intravenous drip effect. The dosage of antibiotics should be sufficient and continue to be given for 2 weeks after the disappearance of symptoms to consolidate the effect to avoid the formation of chronic pelvic inflammatory disease. The following antibiotics can be used for acute pelvic inflammatory disease: second generation cephalosporins or drugs equivalent to second generation cephalosporins, and third generation cephalosporins or drugs equivalent to third generation cephalosporins (cefoxitin sodium, cefotetan disodium, doxycycline, cefuroxime sodium, ceftizoxime sodium, ceftriaxone sodium, cefotaxime sodium). In patients with tubo-ovarian cysts, clindamycin or metronidazole may be added to more effectively combat anaerobic bacteria. A combination regimen of clindamycin and aminoglycoside drugs, a combination regimen of quinolones and metronidazole, and a combination regimen of penicillins and tetracyclines may also be used in patients with acute pelvic inflammatory disease. Therefore, the onset of acute pelvic inflammatory disease should be treated at the hospital according to medical advice to avoid delaying the disease.