Chronic pelvic pain syndrome (CPPS) refers to type III prostatitis in the National Institutes of Health (NIH) classification of prostatitis and is mainly characterized by pain in the pelvic region, which can be found in the perineum, penis, perianal area, urethra, pubic bone and lumbosacral region. Although there is no specific name for chronic pelvic pain syndrome in ancient Chinese medical texts, this disease can be discussed in the category of “seminal turbidity” and “pain” based on its pain-based clinical manifestations. In the system of Chinese medicine, there are various causes of pain, and pain caused by blood stasis is the most common. Many scholars have suggested that stasis should be considered as the main pathogenesis of type III prostatitis [1]. The stasis of blood in chronic pelvic pain syndrome can be further subdivided into damp-heat stasis, qi stagnation and blood stasis, and kidney deficiency and cold blood stasis. At present, the treatment of chronic pelvic pain syndrome by activating blood circulation and resolving blood stasis has achieved more satisfactory efficacy, and the clinical reports in recent years are reviewed here. This method is applicable to chronic pelvic pain syndrome with dampness and heat stasis as the main pathogenesis. The main clinical manifestations are chronic pelvic pain and discomfort, frequent urination, urgent urination, painful urination, short yellow urine, incomplete dripping, thin and unformed stool, greasy mouth and heavy body, yellow tongue coating, moist pulse, etc. The prostate gland is located in the lower jiao, and dampness tends to go down. If the phase fire is not emitted for a long time, or if the external heat and dampness are not emitted, dampness and heat flow into the lower jiao, and at the same time heat and blood cause stasis, the disease will develop. Some scholars [2] pointed out that damp-heat stasis is the basic pathogenesis of chronic prostatitis, while damp-heat with stasis is the most common clinical evidence of TCM. The treatment should be to activate blood circulation and remove stasis, and also to clear damp-heat. Guan Chunhui [4] used the treatment of 30 cases of type IIIA prostatitis with 2 weeks as a course of treatment (12 g of Angelica sinensis, 12 g of Chuanxiong rhizome, 15 g of red peony, 12 g of peony skin, 15 g of Buddha’s hand, 15 g of tiger scepter, 15 g of Quema, 15 g of Cao, 15 g of Poria, 15 g of Poria, 12 g of Phellodendron, 15 g of Dandelion, 12 g of Yujin, 12 g of Yanhuosuo), The total effective rate was 90.0%. Xu Xinjian et al [5] applied the method of clearing heat and resolving stasis (red vine 30 g, white flowered snake tongue grass 30 g, dandelion 10 g, zedoary 10 g, cypress 15 g, zelenium 10 g, danshen 15 g, peach kernel 10 g, wang bu liuxing 12 g, wild chrysanthemum 10 g, deer artichoke 15 g) to treat 80 cases of chronic non-bacterial prostatitis, and the total effective rate was 81?25%. Lu Shengyuan [6] treated 40 cases of chronic prostatitis with the method of activating blood circulation, removing blood stasis, clearing heat and relieving dampness, with a total effective rate of 80.0%. Cheng Haisheng [7] treated 100 cases of chronic prostatitis with a total effective rate of 92% by applying the method of clearing heat, promoting dampness, activating blood circulation and removing blood stasis. Yi Chun You [8] applied the method of clearing dampness and heat, activating blood circulation and removing blood stasis to treat 56 cases of chronic bacterial prostatitis, with a total effective rate of 91.7%. This method is applicable to chronic pelvic pain syndrome with qi stagnation and blood stasis as the main pathogenesis. The main clinical manifestations are pelvic pain and discomfort, which can lead to testicular pain, urinary frequency, urinary urgency, urinary pain, dripping urine, emotional and mental discomfort, good breath, chest and hypochondriacal pain, and astringent pulse. Ling Shu? The “meridian” said: “the liver and feet of the fructus yin pulse, starting from the hair of the big finger ……, following the femoral yin into the hair, over the pubic apparatus, to the small abdomen”. The actual fact is that the prostate gland is closely linked to the liver meridian. Blood Evidence Theory? It is said in the Treatise on Blood Evidence: “The anterior yin belongs to the liver, and the liver fire is angrily moved, resulting in incompetence in the stem”. Some scholars [9] believe that both the physiological function of the liver, the circulation of the meridians and the method and prescriptions for regulating the liver can explain the mechanism of chronic non-bacterial prostatitis treated from the liver. The main reason for this is that the liver and blood stagnation is one of the main pathological mechanisms of chronic nonbacterial prostatitis. The treatment should be based on de-stagnation of liver qi and activation of blood. Cai JG et al [11] applied the method of regulating qi and invigorating blood (Qing Pi 10 g, Wu Yao 10 g, Cumin 10 g, Orange Kernel 10 g, Wang Bu Liu Xing 15 g, Hawthorn 30 g, Dan Shen 20 g, Red Peony 15 g, Jin Yin Hua 30 g, and Fructus Cuspidatum 15 g) to treat 65 cases of chronic non-bacterial prostatitis. After 2 months of treatment, the total effective rate was 89?23%. Feng Ziju [12] treated 128 cases of chronic non-bacterial prostatitis from liver theory, and the evidence was divided into 3 types: liver qi stagnation, liver and spleen disorder, and liver depression and kidney deficiency. The total effective rate was 98.7%. Fang Zhenqiang et al [13] applied the method of tonifying the spleen, draining the liver and activating blood to treat 42 cases of chronic prostatitis, with a total effective rate of 85?7%. Mo Liangming [14] treated 40 cases of type IIIB prostatitis with Chai Hu Shu Hepatic San combined with Tao Hong Si Wu Tang, with an overall effective rate of 87.5%. Chen Chengbo et al [15] treated 78 cases of chronic prostatitis with a total effective rate of 82.1% by applying the method of dredging the liver and activating blood. Dong Jian et al [16] treated 62 cases of chronic non-bacterial prostatitis with liver stagnation and qi stagnation by applying liver clearing and tonifying soup, with a total effective rate of 100%. Chen H.Y. et al [17] applied Plus flavor prostate soup to treat 84 cases of non-bacterial chronic prostatitis with qi stagnation and blood stasis, with a total effective rate of 91.7%. This method is applicable to chronic pelvic pain syndrome with kidney deficiency, cold stagnation and blood stasis as the main pathogenesis, which mainly manifests as chronic pelvic pain, frequent urination, urinary urgency, painful urination, dripping urine, shortness of breath, lack of vitality, lack of color, fear of cold, tiredness of limbs, loss of libido, pale tongue, white fur, and thin pulse. The tongue is pale with white fur and the pulse is weak. The “Treatise on the Origin of Diseases” says: “The kidney is weak, unable to store water, the cell is cold, so after urinating the water does not stop, and there is residual leaking.” The operation of qi and blood depends on the yang of the kidney. Excessive indulgence in sex, excessive use of bitter and cold products, old age and weakness, and prolonged illness all tend to deplete the yang of the kidney. Insufficient yang energy, cold stagnation, blood stasis, blood and Qi, followed by glandular congestion, and the inability to drive out the evil, the development of the disease. Treatment should be based on tonifying the kidney, warming the Yang and activating the Blood. The most important thing is that the body of the patient has to be warmed up and the blood is not so hot. Yang Liwei et al [21] applied the method of warming yang and activating blood circulation (consisting of Huang Qi, Raspberry, Tiger Balm, Angelica sinensis, Tao Ren, Tu Fu Ling and Rhubarb) to treat 30 cases of chronic prostatitis with a total effective rate of 83?3%. Gao Zheng [22] applied the method of tonifying the kidneys, strengthening the spleen and promoting stasis to treat 63 cases of chronic prostatitis with kidney deficiency, with 4 weeks as a course of treatment and a total of 3 courses of treatment, and the total effective rate was 90?5%. The total effective rate was 95.5% in 270 cases of type IIIA prostatitis treated with ion introduction of the formula of tonifying the kidney and activating blood by Wan Shou Cong et al [23]. Ju Baojun et al [24] treated 50 cases of chronic prostatitis with the application of kidney tonifying and blood invigorating Chinese medicine via rectal administration, with a total effective rate of 80.0%. Wu Daosheng [25] treated 42 cases of chronic prostatitis with a total effective rate of 92.9% by applying tonifying kidney and blood circulation herbs combined with hot compresses. Liu Xiaohui [26] applied Qing tonic and blood-activating soup to treat 80 cases of prostatitis, and the total effective rate was 97.5%. Zhao Pengfei et al [27] applied the method of removing blood stasis and tonifying the kidney to treat 25 cases of chronic prostatitis, with an overall efficiency of 92.0%. In conclusion, because the pathogenesis of chronic pelvic pain syndrome is unknown and there are some differences in the understanding of various schools, it is difficult to treat. At present, the method of activating blood circulation and removing blood stasis is widely used in the treatment of chronic pelvic pain syndrome, and has achieved more satisfactory results. It is proved in modern medicine [28] that the method of removing blood stasis can make the blood vessels in the prostate dilate, accelerate blood circulation, strengthen oxygen supply to the tissue, and make the blood-stasis-activating drugs work directly on the prostate to improve local microcirculation and unblock the prostatic ducts, which has the effect of inhibiting the release of inflammatory mediators, anti-fibrosis, and regulating immune function. Some scholars [29] pointed out that blood circulation and blood stasis activation alone or in combination have different degrees of improving the degree of blood flow, dilating blood vessels, reducing blood viscosity and capillary permeability, and improving microcirculation. The pathogenesis of blood stasis in chronic pelvic pain syndrome can be further subdivided into damp-heat stagnation, qi stagnation and blood stasis, and kidney deficiency and cold stagnation. In addition, some scholars [30] applied the method of nourishing Yin and invigorating Blood to treat chronic prostatitis with satisfactory results; some scholars [31] applied the method of benefiting Qi and resolving blood stasis to treat chronic nonbacterial prostatitis with more satisfactory results. Thus, under the guidance of TCM theory and on the basis of rational identification, the method of invigorating blood and resolving blood stasis is an important method for the treatment of chronic pelvic pain syndrome and has strong clinical guidance significance.