The detection of sperm DNA fragmentation rate is very important for infertility patients. Traditional routine semen examination can reflect semen quality in terms of sperm concentration and sperm motility, but its value in evaluating sperm function is limited and does not directly reflect the ability of sperm to fertilize and its effect on embryo development. Studies have shown that the rate of sperm DNA fragmentation in patients with infertility is significantly higher than that in normal subjects. Even if the other indicators of semen are normal, it does not mean that the sperm DNA fragmentation rate is normal. Three types of men should be tested for sperm DNA fragmentation rate: 1. male patients whose spouses have a history of spontaneous abortion Sperm DNA, as a carrier of genetic material, is not only significantly correlated with sperm function, but can also affect the division of fertilized eggs and the development of embryos. 2.Patients with unexplained infertility There are many patients with normal results of routine semen analysis who were previously diagnosed with unexplained infertility and now have been examined and found to have a high rate of sperm DNA fragmentation and have been given the opportunity to have children after targeted treatment. 3. Patients who are ready for IVF Research has proven that it has a great relationship with IVF success rate because IVF, which avoids part of the natural conception process of superiority and natural selection, and high sperm DNA fragmentation rate may lead to a decrease in sperm fertilization ability, resulting in egg fertilization failure. Even if the eggs are fertilized and developed into embryos through second-generation IVF (ICSI), DNA-damaged sperm can lead to poor quality embryos after fertilization and serious disruptions in embryo development, resulting in failure of embryo implantation into the uterus and embryo development defects, which can eventually lead to miscarriage. How to reduce the rate of sperm DNA fragmentation? Bad habits such as smoking, alcoholism and staying up late, long-term exposure to polluted air, high heat, toxins and radiation, reproductive gland infections and inflammation (epididymitis, prostatitis or seminal vesiculitis, etc.), leukocytosis in semen, varicocele and other diseases are all harmful factors that lead to a higher sperm DNA fragmentation rate. 1.First of all, you should correct bad habits (smoking, alcoholism and staying up late), regulate work stress and improve sleep quality; avoid long-term exposure to harmful environments such as high temperature, polluted air, toxic substances and radiation exposure. 2, treatment of related physical diseases, such as the use of antibiotics to treat reproductive gland infections and inflammation, surgery to treat varicocele. 3.Chinese herbal medicine has advantages in treating sperm DNA damage. Studies have confirmed that drug treatment can significantly improve the integrity of sperm DNA, improve semen quality and increase the conception success rate of spouses of infertility patients. 4. Medications such as vitamin E and vitamin C and some micronutrient supplementation treatments also help to reduce the rate of sperm DNA fragmentation. These treatments help patients succeed in having a healthy baby. At present, our fertility center has carried out tests such as the sperm DNA integrity test, and patients with abnormally high sperm DNA fragmentation rates are given medication along with health guidance, which has been proven to be effective in clinical studies.