Perirenal infections can be treated with penicillin or cephalosporin antibiotics. Perirenal infections are usually caused by bacterial infections with symptoms such as back pain and fever, and are treated with antibacterial and anti-inflammatory therapy. Blood culture and drug sensitivity test should be given along with the treatment to clarify the causative organism and select the appropriate antibiotics. The commonly used antibiotics are penicillin and cephalosporins. The commonly used penicillin antibiotics are amoxicillin clavulanate potassium, meloxicillin sodium and other drugs, and the commonly used cephalosporin antibiotics are ceftriaxone sodium, cefoperazone sodium sulbactam sodium and other drugs. The condition can be cured by active antibacterial and anti-inflammatory treatment for perirenal inflammation.