Whether vaccination can be given on the last day of the menstrual period depends on the health condition of the vaccine recipient and the type of vaccine. If there are no uncomfortable symptoms such as breast swelling, lower abdomen and back pain, diarrhea, etc. on the last day of the physiological period, some vaccines can be administered; if the above uncomfortable symptoms occur, you need to wait 2-3 days after the end of menstruation before vaccination. Since the immunity of the female organism decreases during the menstrual period, vaccination with HPV vaccine, hepatitis B vaccine, influenza vaccine and chickenpox vaccine may cause menstrual pain and prolonged periods, so such vaccinations are not recommended during menstruation. In contrast, the New Crown vaccine, tetanus vaccine, and rabies vaccine can be administered even during the physiological period. Before vaccination, you need to inform the health care provider in advance of your special condition, such as whether you are in your physiological period, suffering from acute infectious diseases or serious chronic diseases, etc., so that the health care provider can judge whether vaccination is possible. After vaccination, you should stay in the observation room for at least 30 minutes and leave only if you are not unwell. If you experience fever, fatigue, dizziness, nausea, vomiting and other discomfort after vaccination, which improves after rest, it may be a common adverse reaction and there is no need to worry too much. If the symptoms of discomfort are more serious and do not improve, you should inform the health care provider in time and let them handle the situation accordingly.